Bispecific Antibodies

EHR Implementation of Bispecific Agents for Multiple Myeloma
In this eighth installment, Kristen Boykin, PharmD, RPh/CPh, BCOP, BCPS, and Yonatan Resnick, PharmD, discuss considerations for preparing a healthcare center’s electronic health record to accommodate bispecific agents in multiple myeloma treatment.
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Total Cost of Care for Bispecific Agents in Multiple Myeloma
In this seventh installment, Lisa Raff, PharmD, MSPharm, BCPS, BCOP, and Laura Bobolts, PharmD, BCOP, discuss total cost of care associated with bispecific agents and other multiple myeloma treatments, as well as how that compares to the outcomes being produced.
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Payer Policy Development for Bispecific Agents in Multiple Myeloma

In this fifth installment, Laura R. Bobolts, PharmD, BCOP, and Lisa Raff, MSPharm, BCPS, BCOP, discuss payer considerations when considering reimbursement and formulary inclusion of bispecific agents, as well as how payers keep up-to-date on the evolving landscape of multiple myeloma learning opportunities from bispecific therapy REMS programs.

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Team Education for Bispecific Usage in Multiple Myeloma

In this second installment, Hakan Kaya, MD, and Yonatan Resnick, PharmD, discuss staff educational needs and experiences implementing staff education for bispecific agents in multiple myeloma.

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On June 26, 2024, the FDA approved epcoritamab-bysp (Epkinly; Abbvie and Genmab) as the first and only T-cell engaging bispecific antibody administered subcutaneously for the treatment of adults with relapsed or refractory follicular lymphoma (FL) after ≥2 lines of prior therapy.
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On May 21, 2021, the FDA accelerated the approval of amivantamab-vmjw (Rybrevant; Janssen/Johnson & Johnson), a bispecific antibody targeting mutations in the EGFR and MET pathways, for adults with non–small-cell lung cancer (NSCLC) that is associated with EGFR exon 20 insertion mutations, as detected by the FDA-approved Guardant360 CDx test, which was approved on the same day as a companion diagnostic for amivantamab. The FDA had granted amivantamab a breakthrough therapy designation for this indication.
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Bispecific antibodies are showing promise in patients with hematologic malignancies, notably relapsed or refractory multiple myeloma. Results from studies of 3 bispecific antibodies were presented at ASH 2020, showing deep and durable responses.
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