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ASCO 2015 Highlights
Genetic Abnormality Pinpointed for Intensive Therapy in Wilms Tumor
By
Phoebe Starr
ASCO 2015 Highlights
,
ASCO
July 2015, Vol 6, No 6
Chicago, IL—In children who are at risk for Wilms tumor, the presence of a rare genetic abnormality identifies children who can have a survival benefit from the augmentation or intensification of therapy. The abnormality—loss of heterozygosity (LOH) on chromosomes 1p and 16q (LOH 1p/16q)—is associated with worse prognosis in children with Wilms tumor.
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Two Large National Personalized Medicine Clinical Trials Are Launched by ASCO and NCI
By
Dana Taylor
ASCO 2015 Highlights
,
ASCO
July 2015, Vol 6, No 6
Chicago, IL—Precision medicine in oncology is now being studied in clinical trials in oncology. These trials will pair a patient’s tumor molecular profile with drugs that address those tumor variants.
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Lenvatinib Extends Survival in Metastatic Renal-Cell Carcinoma
By
Wayne Kuznar
ASCO 2015 Highlights
,
ASCO
July 2015, Vol 6, No 6
Chicago, IL—Lenvatinib (Lenvima) added to everolimus (Afinitor) extended overall survival (OS) significantly compared with everolimus alone in patients with metastatic renal-cell carcinoma (RCC). This phase 2 study also demonstrated improved progression-free survival (PFS) with lenvatinib alone and in combination with everolimus compared with everolimus alone.
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Current Cost of Cancer Drugs Does Not Reflect Value, One Oncologist Suggests
By
Dana Taylor
ASCO 2015 Highlights
,
ASCO
July 2015, Vol 6, No 6
Chicago, IL—According to Leonard B. Saltz, MD, Chief of Gastrointestinal Oncology at Memorial Sloan Kettering Cancer Center, NY, the cost of new cancer drugs is no longer sustainable. Dr Saltz presented “Perspectives on Value” at the Plenary Session of the 2015 American Society of Clinical Oncology meeting.
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Elotuzumab, First-in-Class Monoclonal Antibody Immunotherapy, Improves Outcomes in Patients with Multiple Myeloma
By
Phoebe Starr
ASCO 2015 Highlights
,
ASCO
June 2015, Vol 6, No 5
Elotzumab’s “double whammy” mechanism of action acts directly on the tumor itself and enhances the activity of natural killer cells to kill the tumor.
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Combination Immunotherapy Superior to Monotherapy in Patients with Melanoma
By
Chase Doyle
ASCO 2015 Highlights
,
ASCO
June 2015, Vol 6, No 5
Combination treatment with nivolumab and ipilimumab doubled progression-free survival in patients with advanced melanoma, according to CheckMate 067 investigators.
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Docetaxel Boosts Survival in Patients with Hormone-Naïve Metastatic Prostate Cancer
By
Phoebe Starr
ASCO 2015 Highlights
,
ASCO
June 2015, Vol 6, No 5
Chicago, IL—Adding docetaxel (Taxotere) to standard hormone therapy extends overall survival (OS) by a median of 10 months versus hormone therapy alone in men with newly diagnosed, advanced, hormone therapy–naïve prostate cancer, according to the results of the STAMPEDE trial. The survival benefits were more pronounced in metastatic disease and were less certain in nonmetastatic disease. Another finding of this analysis of STAMPEDE is that zoledronic acid (Zometa) had no benefit in this setting.
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Immunotherapy Makes Headwinds into Liver Cancer
By
Wayne Kuznar
ASCO 2015 Highlights
,
Immunotherapy
,
ASCO
June 2015, Vol 6, No 5
Chicago, IL—Immunotherapy with nivolumab (Opdivo) resulted in durable responses and promising overall survival (OS) in a dose-escalation and expansion trial of patients with advanced liver cancer. The 12-month OS rate exceeded 60% in patients in whom sorafenib (Nexavar) had failed, and responses occurred in patients with the hepatitis B virus (HBV) or hepatitis C virus (HCV) infection, reported Anthony B. El-Khoueiry, MD, Assistant Professor of Clinical Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, at the 2015 American Society of Clinical Oncology (ASCO) meeting.
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Oral Nicotinamide Prevents Common Skin Cancers in High-Risk Patients
By
Phoebe Starr
ASCO 2015 Highlights
,
ASCO
June 2015, Vol 6, No 5
Chicago, IL—The prevention of common skin cancers and precancers is possible by taking an inexpensive, widely available, oral pill twice daily. The pill—the vitamin B3 supplement called nicotinamide—cut the rate of new squamous-cell and basal-cell skin cancers by 23% compared with placebo after 1 year among patients at high risk for skin cancer. Nicotinamide also reduced the risk for developing actinic keratosis, a common precancer of the skin.
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Encouraging Results for Pembrolizumab in Head and Neck Cancer
By
Phoebe Starr
ASCO 2015 Highlights
,
ASCO
June 2015, Vol 6, No 5
Chicago, IL—Pembrolizumab (Keytruda) achieved “remarkable” results in a phase 1 study of previously treated patients with recurrent, squamous-cell carcinoma of the head and neck, according to presenters at the 2015 American Society of Clinical Oncology (ASCO) annual meeting.
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Home
Issues
Online First
Latest Issue
Issue Archive
Special Issues
Browse By Topic
Personalized Medicine
Economics & Value
FDA Approvals, News & Updates
COVID-19
Cholangiocarcinoma
View All Topics ›
Conference Correspondent
SABCS 2023 - HER2+ MBC
ASCO 2023 - Breast Cancer
Web Exclusives
Web Exclusive Articles
Videos
Interview with the Innovators
Prostate Cancer Diagnostics Monthly Minutes
Webinars
Quick Quizzes
Press Releases
AVBCC
Association for Value-Based Cancer Care
VBCM
Value-Based Care in Myeloma