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Bladder Cancer
Immunotherapy After Surgery Shows Long-Term Benefits for High-Risk Bladder Cancer
Bladder Cancer
Online First
Updated results from a large clinical trial confirm that, for some patients with bladder cancer that can be removed with surgery, receiving immunotherapy immediately afterwards is an effective treatment.
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Addressing Health Equity in Bladder Cancer Care
By
Wayne Kuznar
ASCO GU 2023 HIGHLIGHTS
,
Bladder Cancer
,
Genitourinary Cancers
April 2023, Vol 14, No 2
During the 2023 American Society of Clinical Oncology Genitourinary Cancers Symposium, a panel of experts identified some of the key challenges to achieving health equity in bladder cancer care and discussed what can be done to improve access to clinical trials, mitigate financial toxicity, and promote value-based care.
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Adstiladrin, First Adenoviral Vector–Based Gene Therapy, FDA Approved for High-Risk Non–Muscle Invasive Bladder Cancer
FDA Approvals, News & Updates
,
Bladder Cancer
,
Genitourinary Cancers
February 2023, Vol 14, No 1
On
December 22, 2022
, the FDA accelerated the approval of mosunetuzumab-axgb (Lunsumio; Genentech), a bispecific CD20-directed CD3 T-cell engager, for adults with relapsed or refractory follicular lymphoma after ≥2 lines of systemic therapy. The FDA granted this indication breakthrough therapy and orphan drug designations.
Read Article
Enfortumab Vedotin Demonstrates Superior Efficacy versus Chemotherapy in Bladder Cancer
Bladder Cancer
,
In the Literature
Web Exclusives
Patients with advanced urothelial carcinoma and disease progression after treatment with platinum-based chemotherapy and PD-1 or PD-L1 inhibitors have limited treatment options. Enfortumab vedotin (Padcev), a Nectin-4–directed antibody and microtubule inhibitor conjugate, demonstrated an objective response rate (ORR) in more than 40% of patients with advanced urothelial carcinoma who had progression after previous treatment.
Read Article
Maintenance Avelumab New Standard of Care for Advanced Bladder Cancer
By
Phoebe Starr
Bladder Cancer
August 2020, Vol 11, Special Issue: Payers' Perspectives in Oncology
Interim analysis of the phase 3 JAVELIN Bladder 100 clinical trial showed that maintenance therapy with the PD-L1 inhibitor avelumab (Bavencio) plus best supportive care significantly prolonged overall survival (OS) versus best supportive care alone in patients with advanced urothelial carcinoma whose disease did not progress with first-line platinum-based chemotherapy.
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Adjuvant Atezolizumab Did Not Show Disease-Free Survival Benefit in High-Risk Urothelial Cancer
By
Phoebe Starr
Bladder Cancer
August 2020, Vol 11, Special Issue: Payers' Perspectives in Oncology
Adjuvant therapy with atezolizumab (Tecentriq) did not meet the primary end point of disease-free survival (DFS) in patients with muscle-invasive urothelial cancer (MIUC) at high risk for recurrence versus observation alone in the primary analysis of the IMvigor010 trial.
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FDA Grants Priority Review to Keytruda for Patients with High-Risk, Non–Muscle-Invasive Bladder Cancer
By
Yvette Florio Lane
Bladder Cancer
,
FDA Approvals, News & Updates
,
Immunotherapy
Web Exclusives
On December 2, 2019, Merck announced that the FDA has granted priority review for its supplemental biologics license application for the anti–PD-1 agent pembrolizumab (Keytruda).
Read Article
Tecentriq (Atezolizumab) Receives New Indication for First-Line Treatment of Locally Advanced or Metastatic Urothelial Carcinoma
By
Lisa A. Raedler, PhD, RPh
Bladder Cancer
,
FDA Approvals, News & Updates
2018 Third Annual Oncology Guide to New FDA Approvals
Urothelial carcinoma is the most common subtype of bladder cancer, accounting for more than 90% of bladder cancer diagnoses in the United States. In 2017, more than 79,000 bladder cancer cases were diagnosed in the United States, and more than 16,000 people died from this disease. The prognosis is favorable for patients with localized disease, with a 5-year relative survival rate of 78% for all stages of bladder cancer, which decreases to 5% for patients with distant disease.
Read Article
Imfinzi (Durvalumab) a New PD-L1 Inhibitor Approved for the Treatment of Advanced or Metastatic Urothelial Cancer
By
Lisa A. Raedler, PhD, RPh
Bladder Cancer
,
FDA Approvals, News & Updates
2018 Third Annual Oncology Guide to New FDA Approvals
Urothelial carcinoma is the primary subtype of bladder cancer, which is the sixth most common cancer in the United States. More than 79,000 cases of bladder cancer were estimated to be diagnosed, and nearly 17,000 people to die from this disease in 2017.
Read Article
Atezolizumab Could Be Start of “Seismic Shift” in Metastatic Bladder Cancer Therapy
By
Wayne Kuznar
Bladder Cancer
,
Solid Tumors
August 2016, Vol 7, No 7, Special Issue: Payers’ Perspectives in Oncology
Atezolizumab (Tecentriq) shows promise as primary therapy in patients with cisplatin-ineligible, locally advanced metastatic urothelial (bladder) cancer, according to data from the IMvigor210 study presented at ASCO 2016.
Read Article
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