Articles

Managing CCA Patients While Waiting for Molecular Biomarker Testing Results
Dr Vaibhav Sahai and Dr Angela Lamarca consider options for managing patients with CCA while awaiting results from biomarker testing, which can take 3 to 6 weeks. They discuss starting these patients on first-line chemotherapy and then switching appropriate patients to second-line targeted therapy, and also speak to the increased utility of next-generation sequencing in CCA.
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AVBCC: The Prime Venue for Candid Conversations About Value in Cancer Care
AVBCC Co-Chair Barry Brooks describes how the AVBCC Summit is a premier opportunity to discuss the future of cancer care with some of the most knowledgable industry leaders, practitioners, pharmacists, payers, policymakers, and C-suite executives.
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AVBCC Provides Real-World Discussions for All Cancer Care Stakeholders
AVBCC Co-Chair William McGivney talks about what attendees can expect to gain from the AVBCC Summit, and why the value equation in cancer care is an issue that affects all stakeholders in the oncology space.
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Why Invest in the AVBCC Summit?
Watch AVBCC Co-Founder and Chairman Burt Zweigenhaft as he explains what differentiates the AVBCC Summit from other oncology meetings and why you can't afford to miss out on this unique gathering of stakeholders from all facets of the cancer care spectrum.
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On January 29, 2020, Eli Lilly announced that the FDA granted priority review to their New Drug Application for selpercatinib (LOXO-292) for the treatment of patients with advanced RET fusion-positive non–small-cell lung cancer, RET-mutant medullary thyroid cancer, and RET fusion-positive thyroid cancer.
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The Use of Molecular Biomarker Testing in Patients with CCA
Dr Vaibhav Sahai discusses different approaches to molecular biomarker testing, including when to order the tests in the course of the disease, use of institutional and commercial testing facilities, and what platforms exist for testing.
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On January 23, 2020, the FDA granted accelerated approval to tazemetostat (Tazverik; Epizyme), a methyltransferase inhibitor, for the treatment of metastatic or locally advanced epithelioid sarcoma in adults and pediatric patients aged ≥16 years who are not eligible for complete resection.
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On January 8, 2020, the American Cancer Society published details of their annual cancer statistics report, including the most recent data on population‐based findings for cancer incidence through 2016 and for mortality through 2017 (CA Cancer J Clin. 2020;70:7-30). The report revealed encouraging news as well as some sobering trends.
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Results from TRANSCEND CLL 004 showed chimeric antigen receptor (CAR) T-cell treatment with lisocabtagene maraleucel in heavily pretreated patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) who had failed ibrutinib was manageable and produced durable undetectable minimal residual disease responses.
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Results from the 3-year update of the phase 2 AIM trial confirmed the effectiveness of ibrutinib + venetoclax therapy for patients with mantle-cell lymphoma, and indicated that treatment interruption was feasible for patients in minimal residual disease–negative complete remissions.
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