Articles

As many as 15% to 30% of patients who receive BRAF inhibitors (eg, vemurafenib, dabrafenib) for the treatment of metastatic melanoma develop nonmelanoma skin cancers. Data from a new study suggest that this paradoxical effect may be caused by squamous-cell carcinoma cell lines with RAS mutation that proliferate on exposure to these drugs (Su F, et al. N Engl J Med. 2012;366:207-215).

Several studies have suggested that statins may have protective effects against cancer. The results of the first study to investigate the association between statin therapy in patients with chronic hepatitis B virus (HBV) infection and the risk for hepatocellular carcinoma (HCC) were recently published (Tsan YT, et al. J Clin Oncol. 2012;30:623-630).

A new study has now investigated the prognosis of patients with gastric cancer who have a family history of the disease and have undergone gastrectomy (Han MA, et al. J Clin Oncol. 2012;30:701-708).

The treatment options for myelofibrosis are very limited, with ruxolitinib the potent Janus kinase (JAK) 1 and 2 inhibitor, being the first and only drug approved specifically for this condition late last year.

Findings from 2 separate studies have shown that adding the vascular endothelial growth factor inhibitor bevacizumab to adjuvant chemotherapy regimens improves response rates in patients with early-stage breast cancer (Bear HD, et al. N Engl J Med. 2012;366:310-320; von Minckwitz G, et al. N Engl J Med. 2012;366:299-309).

Professor Jonathan Waxman, of Imperial College London, an expert in prostate cancer who founded the Prostate Cancer Charity in England and helped garner support for cancer treatment, has denounced the refusal of the UK National Institute for Health and Clinical Excellence (NICE) to approve the 2 new and expensive prostate cancer drugs approved last year in the United States, saying that NICE "has overregulated and proscribed drugs that offer real advances to people with cancer.

The Prostate Cancer Foundation (PCF) is expanding its efforts to encourage innovation in prostate cancer research.

An online tool launched by the National Institutes of Health (NIH) will help patients, providers, and researchers navigate the rapidly growing landscape of genetic testing, many of them associated with cancer therapy.

Results of a new survey of primary care physicians (PCPs) show that 1 in 3 PCPs believe that ovarian cancer screening is safe and effective, contrary to current evidence. The survey was published in the February 7, 2012, issue of Annals of Internal Medicine.

Moffitt Cancer Center in Tampa, FL, has announced it is launching its Personalized Medicine Institute to advance the fight against cancer, and implementing the promise of personalized cancer care medicine by focusing on innovative biotechnology with its biotechnology subsidiary M2Gen.