San Antonio, TX—The addition of an oral investigational agent to letrozole (Femara) for the treatment of estrogen receptor (ER)-positive metastatic breast cancer more than tripled the time spent in remission compared with endocrine therapy alone, according to a study reported at the CTRC-AACR San Antonio Breast Cancer Symposium.[ Read More ]
Vancouver, BC—In the aftermath of the Z0011 study from the American College of Surgeons Oncology Group, oncology centers across the United States are reexamining their approach to axillary management in breast cancer.
The Z0011 researchers determined that axillary lymph node dissection (ALND) is not beneficial in patients with T1 or T2 invasive breast cancer, 1 or 2 positive sentinel nodes, and breast-conserving therapy followed by whole-breast irradiation (Giuliano AE, et al. JAMA. 2011;305:569-575).[ Read More ]
Vienna, Austria—Despite a robust response to neoadjuvant chemotherapy, which renders many early breast cancer tumors resectable, breast-conserving surgery is often overlooked in favor of mastectomy, according to an analysis of the Neo-ALLTO clinical trial, which was presented at the 2012 European Society for Medical Oncology Congress.[ Read More ]
Black Women with Invasive Node-Negative Breast Cancer Less Likely to Get Sentinel Lymph Node Biopsy for Axillary Staging, More Likely to Have Lymphedema
San Antonio, TX—Black women with clinically node-negative invasive breast cancer were less likely than white women to undergo sentinel lymph node biopsy (SLNB) for axillary staging and also were more likely to develop lymphedema, according to a study presented at the CTRC-AACR San Antonio Breast Cancer Symposium.
This study adds to the growing body of evidence documenting racial disparities in healthcare access.[ Read More ]
Vienna, Austria—Several studies presented at the 2012 European Society for Medical Oncology Congress offered a look into what many believe will lead to the application of genome-based biomarker information into clinical use based on the concept of personalized medicine, although not all of the results were unconditionally encouraging.[ Read More ]
?Vienna, Austria—The identification of genetic mutations and tumor biomarkers to select the right drug for the right patient are not enough to satisfy the need for personalized cancer care, according to Kathy Redmond, MSc, RN, Editor of Cancer World magazine, a publication of the European School of Oncology and former president of the European Oncology Nursing Society, who addressed the topic of personalized medicine at the 2012 European Society for Medical Oncology Congress.[ Read More ]
?Phoenix, AZ—Using the paradigm of individualizing drug therapy based on a patient’s genetics, a group of oncologists and genomic experts have designed a genomic prescribing system that they hope will significantly reduce the staggeringly high rate of adverse drug reactions associated with prescription drugs in the United States. Principal investigator Peter H. [ Read More ]
Vienna, Austria—“Is personalized cancer care affordable?” asked Richard Sullivan, MD, PhD, Director of Kings Health Partners Institute of Cancer Policy and Global Health in the United Kingdom, in an invited presentation at the 2012 European Society for Medical Oncology Congress.
The short answer he gave was “no,” barring seismic shifts not only in the oncology landscape but also in the larger societal picture. He described 3 trends that will be disastrous for controlling the cost of care.[ Read More ]
Vienna, Austria—“One of our themes at the 2012 ESMO Congress is personalized oncology,” European Society for Medical Oncology (ESMO) President Martine J. Piccart-Gebhart, MD, PhD, Professor of Oncology at the Université Libre de Bruxelles and Director of the Medicine Department at Jules Bordet Institute, Brussels, Belgium, said at a press briefing at the meeting. She noted that the numerous presentations on targeted therapy and diagnostics at ESMO are evidence that the field is rapidly moving forward.[ Read More ]
Use of Intensity-Modulated Radiotherapy Increasing and Costly in the Management of Head and Neck Cancers, but Value Unknown
Toronto, Canada—The popularity of intensity-modulated radiotherapy (IMRT) for head and neck cancer has climbed rapidly in recent years. However, the extra cost associated with this treatment modality may not equate with improved value, according to researchers from the University of California at Los Angeles (UCLA), who presented their analysis at the 2012 International Conference on Head and Neck Cancer.[ Read More ]