Clinical Research

New Meta-Analysis: Complete Response to Neoadjuvant Therapy in Breast Cancer Predictor of Long-Term Benefit

Audrey Andrews

March 2013, Highlights - Clinical Research

A new meta-analysis confirmed that patients with breast cancer who achieve a pathologic complete response (pCR) to neoadjuvant therapy have a more favorable outcome than those who do not.

Patients who achieved a pCR had a 52% reduction in the probability of an event and a 64% reduction in the probability of death (P <.001 for both), as was shown in the meta-analysis of the Collaborative Trials in Neoadjuvant Breast Cancer (CTNeoBC).

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Evidence Still Cloudy for Anticancer Effects with Metformin

Caroline Helwick

March 2013, Highlights - Clinical Research

Observational studies have sug­gested that the antidiabetes agent metformin (Glucophage) may have anticancer effects. New studies have attempted to confirm this, but the results and their meaning still remain unclear.

Reviewing several studies presented at the meeting, Michael N. Pollak, MD, the Alexander Goldfarb Research Chair in Cancer Research and the Di­rec­tor, Division of Cancer Prevention, De­partment of Oncology, McGill Uni­versity, Montreal, Canada, said that there are many unanswered questions, but that “some of those questions have become clearer.”
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