Cholangiocarcinoma

Medical Management of Patients with Advanced Cholangiocarcinoma

December 2019 Highlights from the First Annual Cholangiocarcinoma Summit - Cholangiocarcinoma

According to several presenters at the First Annual Cholangio­carcinoma Summit, advances in systemic treatment for cholangiocarcinoma (CCA) are emerging, including cytotoxic chemotherapy. Earlier this year, the combination of gemcitabine, cisplatin, and nab-paclitaxel was investigated as first-line therapy in 60 patients with advanced CCA and gallbladder cancer with good performance status.1 Among evaluable patients, the median progression-free survival (PFS) was 11.8 months, the median overall survival (OS) was 19.2 months, and the partial response rate was 45%. Overall, 20% of the patients converted from unresectable to resectable disease and underwent curative surgery. [ Read More ]

Updates on the Understanding of Cholangiocarcinoma

December 2019 Highlights from the First Annual Cholangiocarcinoma Summit - Cholangiocarcinoma

On October 17 and 18, 2019, a group of international experts convened in Phoenix, AZ, for the First Annual Cholangiocarcinoma Summit. The goal of the meeting was to discuss the latest clinical data on the disease, as well as the implications of these findings for providers and patients. Each topic included in the summit was presented by 2 speakers and then analyzed by a chorus of experts in the field. This format was chosen to provide a consensus, whenever possible, on each topic that was presented. [ Read More ]

Pemigatinib Effective in Patients with Cholangiocarcinoma and FGFR2 Fusion or Rearrangement

Wayne Kuznar

December 2019, Vol 10, No 6 - Cholangiocarcinoma

Barcelona, Spain—Alterations in the fibroblast growth factor receptor (FGFR)2 gene have been identified as driver mutations in cholangiocarcinoma (CCA). Durable objective responses were observed in >33% of patients with locally advanced or metastatic CCA and FGFR2 rearrangements or fusions who received treatment with pemigatinib, a selective oral inhibitor of FGFR1, FGFR2, and FGFR3. Data from the single-arm, open-label phase 2 clinical trial FIGHT-202, which was presented at the ESMO Congress 2019, revealed that investigational pemigatinib induced a response in 35.5% of the 107 patients with FGFR2 fusions or rearrangements (cohort A), with a median duration of response of 7.5 months. [ Read More ]

Practice-Changing Results: Ivosidenib First Targeted Therapy to Show Benefits in Patients with Cholangiocarcinoma and IDH1 Mutation

Wayne Kuznar

December 2019, Vol 10, No 6 - Cholangiocarcinoma

Barcelona, Spain—Ivosidenib (Tib­sovo), an oral therapy that targets isocitrate dehydrogenase-1 (IDH1) mutation, significantly improved progression-free survival (PFS) in patients with advanced cholangiocarcinoma (CCA) and an IDH1 mutation, in a phase 3 clinical trial reported lead investigator Ghassan K. Abou-Alfa, MD, Medical Oncologist, Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York City, at the ESMO Congress 2019. [ Read More ]

Noninvasive Molecular Diagnosis Using Circulating DNA Sequencing Improves Outcomes in Cholangiocarcinoma Management

Wayne Kuznar

October 2019, Vol 10, No 5 - Cholangiocarcinoma

Diagnosis of cholangiocarcinoma (CCA) is often identified at a late stage. Analyzing the tumor-specific mutation profile of a patient with CCA can improve the diagnosis and treatment for the individual patient. The molecular profile of CCA can be done through the use of circulating tumor (ct) DNA sequencing, which may help to target specific mutations and improve treatment selection for this rare type of cancer. [ Read More ]

Expanding Treatment Options for Patients with Advanced Cholangiocarcinoma

Wayne Kuznar

August 2019, Vol 10, No 4 | Payers’ Perspectives In Oncology: ASCO 2019 Highlights - Cholangiocarcinoma, Liver Cancer

Chicago, IL—A greater understanding of the biology of cholangiocarcinoma, including differences between intrahepatic versus extrahepatic cholangiocarcinoma, is driving the development of new therapeutic options that have shown promising results in advanced stages of this difficult-to-treat cancer. Patients whose disease progressed [ Read More ]