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ASH 2017 - Acute Myeloid Leukemia
Nivolumab plus Azacitidine Shows Encouraging Activity in R/R AML or as Frontline Therapy in Elderly Patients with AML
ASH 2017
,
ASH 2017 - Acute Myeloid Leukemia
,
ASH Highlights
Conference Correspondent
Combination treatment with nivolumab plus azacitidine produced encouraging response rates in patients with relapsed or refractory (R/R) acute myeloid leukemia (AML) with poor-risk features, and in elderly patients as frontline therapy.
Read Article
Dual FLT3 and CDK4/6 Inhibition Shows Modest Activity in Relapsed/Refractory AML
ASH 2017
,
ASH 2017 - Acute Myeloid Leukemia
,
ASH Highlights
Conference Correspondent
A phase 1 dose-escalation study of FLX925, a dual FLT3 and CDK4/6 inhibitor, showed modest antileukemic activity in adult patients with relapsed or refractory acute myeloid leukemia (AML).
Read Article
Continuing Enasidenib Treatment Improves Survival and Responses for Mutant-IDH2 R/R AML Patients with Stable Disease
ASH 2017
,
ASH 2017 - Acute Myeloid Leukemia
,
ASH Highlights
Conference Correspondent
An analysis of response and survival outcomes from the phase 1/2 AG221-C-001 study showed that continued treatment with enasidenib resulted in improved survival and response times in patients with mutant-
IDH2
relapsed or refractory (R/R) acute myeloid leukemia (AML).
Read Article
Lirilumab plus Azacitidine in Heavily Pretreated, Relapsed AML
ASH 2017
,
ASH 2017 - Acute Myeloid Leukemia
,
ASH Highlights
Conference Correspondent
The results of the current phase 1b/2 study showed that the combination of azacitidine plus lirilumab was well-tolerated in heavily pretreated patients with relapsed acute myeloid leukemia (AML) and poor-risk disease features.
Read Article
Venetoclax plus Decitabine or Azacitidine in Treatment-Naïve, Elderly Patients with AML
ASH 2017
,
ASH 2017 - Acute Myeloid Leukemia
,
ASH Highlights
Conference Correspondent
An updated safety and efficacy analysis of a phase 1b study demonstrated a promising benefit–risk profile with the combination of the BCL-2 inhibitor venetoclax with either decitabine or azacitidine in elderly, treatment-naïve patients with acute myeloid leukemia (AML) who are not candidates for intensive standard induction therapy.
Read Article
Addition of Midostaurin to Standard Chemotherapy in RATIFY Decreased CIR in Patients with FLT3-Mutated, Newly Diagnosed AML
ASH 2017
,
ASH 2017 - Acute Myeloid Leukemia
,
ASH Highlights
Conference Correspondent
The results of a post-hoc analysis of the RATIFY trial suggest that midostaurin decreases the cumulative incidence of relapse (CIR) in patients with
FLT3
mutation–positive, newly diagnosed acute myeloid leukemia (AML), with no negative impact on survival.
Read Article
Ivosidenib Monotherapy Results in Deep mIDH1 Clearance in Patients with mIDH1 AML
ASH 2017
,
ASH 2017 - Acute Myeloid Leukemia
,
ASH Highlights
Conference Correspondent
This analysis showed that ivosidenib-treated patients with
IDH1
-mutated (m
IDH1
), relapsed/refractory, and untreated acute myeloid leukemia (AML) whose best response is a complete remission (CR) or CR with partial hematologic recovery achieve m
IDH1
clearance ≤0.04%.
Read Article
Enasidenib Monotherapy Is Well-Tolerated and Active in Older Patients with Untreated mIDH2 AML
ASH 2017
,
ASH 2017 - Acute Myeloid Leukemia
Conference Correspondent
In this subanalysis of the AG221-C-001 phase 1 study, enasidenib monotherapy was found to be well-tolerated, and yielded hematologic responses in previously untreated older patients with
IDH2
-mutated (m
IDH2
) acute myeloid leukemia (AML) who are not fit to receive standard cytotoxic chemotherapy.
Read Article
Ivosidenib or Enasidenib plus Standard Induction Chemotherapy Is Active in Patients with mIDH, Newly Diagnosed AML
ASH 2017
,
ASH 2017 - Acute Myeloid Leukemia
Conference Correspondent
The initial results of a phase 1 study suggest that combination therapy with ivosidenib or enasidenib plus standard induction chemotherapy is well-tolerated and effective in newly diagnosed patients with IDH-mutated (m
IDH
), relapsed/refractory acute myeloid leukemia (AML).
Read Article
Hedgehog Pathway Inhibitor Sonidegib plus Azacitidine in Myeloid Malignancies
ASH 2017
,
ASH 2017 - Acute Myeloid Leukemia
Conference Correspondent
In this analysis, the hedgehog pathway inhibitor sonidegib plus azacitidine combination therapy showed encouraging antileukemia activity in terms of high rate of disease stabilization, particularly in the relapsed/refractory acute myeloid leukemia patient population.
Read Article
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Home
Issues
Online First
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Issue Archive
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Browse By Topic
Personalized Medicine
Economics & Value
FDA Approvals, News & Updates
COVID-19
Cholangiocarcinoma
View All Topics ›
Conference Correspondent
SABCS 2023 - HER2+ MBC
ASCO 2023 - Breast Cancer
Web Exclusives
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Prostate Cancer Diagnostics Monthly Minutes
Webinars
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AVBCC
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Value-Based Care in Myeloma