Russell Knoth

Authored Items

Effects of 5-Hydroxytryptamine-3 Receptor Antagonists (5-HT3 RAs) in Lung Cancer Patients with Multiple Risk Factors

March 2013, Vol 4, No 3 - AVBCC 2013 3rd Annual Conference Abstracts

Background: Chemotherapy induced nausea and vomiting (CINV) is a major adverse effect of cancer treatment. The 5-HT3 RAs are indicated for the prevention of CINV. Certain factors such as age <50 years, female gender, prior CINV, anxiety, no or minimal alcohol use, history of motion sickness, and emetogenicity of chemotherapy have been associated with increasing the likelihood of a CINV event. We examined the impact of palonosetron vs. other 5-HT3 RAs on incidence of delayed CINV at cycle 1 based on presence of certain risk factors in patients with Lung Cancer.

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