Milan—Men with castration-resistant prostate cancer (CRPC) gained 4 months in overall survival (OS) when treated with the novel antiandrogen abiraterone acetate, data from a large randomized trial showed. Treatment with abiraterone and prednisone led to a median OS of 14.8 [ Read More ]
Milan—Continuing first-line chemotherapy for metastatic breast cancer until disease progression significantly improves overall (OS) and progression free survival (PFS), according to a meta-analysis reported at the 35th ESMO Congress Prolonged therapy was associated with a 9% reduction in the mortality [ Read More ]
February 2011, Vol 2, No 1 - Uncategorized
San Antonio, TX—Healthcare costs increase after progression to chemotherapy among postmenopausal pa tients with hormone-sensitive metastatic breast cancer, although ambulatory care drives the cost before and after progression, data from a retrospective chart review showed, as reported at the San [ Read More ]
February 2011, Vol 2, No 1 - Uncategorized
San Antonio, TX—Treatment of recurrent metastatic breast cancer based on reassessment of HER2 status offers the optimal combination of clinical effectiveness and cost, based on 6 different clinical strategies. The largest gain in quality-adjusted life-years (QALYs) with an acceptable incremental [ Read More ]
February 2011, Vol 2, No 1 - Uncategorized
San Antonio, TX—Triple-negative breast cancer not only confers a worse prognosis but it drives up inpatient healthcare costs by almost 50% compared with other types of breast cancer, an analysis of a managed care database suggested. Patients with triple-negative disease [ Read More ]
February 2011, Vol 2, No 1 - Uncategorized
San Antonio, TX—Results of an Italian study showed that use of newer imaging studies in early breast cancer has increased substantially despite a lack of evidence for benefits. Per-patient use of computed tomography (CT), positron-emission tomography (PET), and magnetic resonance [ Read More ]
San Francisco, CA—Within weeks of a government-backed recommendation against routine screening mammography in women aged <50 years, the screening rate had fallen below historic levels and subsequently has remained lower than the baseline rate, a group of researchers reported.[ Read More ]
San Francisco, CA—Women with diabetes taking metformin had a significantly lower risk of breast cancer, an association that appeared to grow stronger with increasing duration of follow-up, results of a recent meta-analysis showed.
Overall, metformin users had a 17% lower risk of breast cancer compared with women who did not use the drug, including diabetic women who were taking other hypoglycemic agents. The reduction in risk increased to 25% among women who took metformin for >3 years and to 32% when follow-up started before 1997.[ Read More ]
Atlanta, GA—Targeting Bruton’s tyrosine kinase (BTK) in patients with chronic lymphocytic leukemia (CLL) resulted in high response rates, without severe toxicity, according to the results of 2 studies that were presented at the 2012 American Society of Hematology meeting.
Data from one trial showed a 70% response rate in 116 patients treated with ibrutinib and a 22-month survival of 96% in previously untreated patients and 76% in the subgroup with relapsed/refractory CLL.[ Read More ]
Atlanta, GA—A chemotherapy-free regimen for patients with acute promyelocytic leukemia (APL) achieved a 2-year survival of almost 100% with less toxicity compared with cytotoxic regimens, according to a study reported at the 2012 American Society of Hematology (ASH) meeting.[ Read More ]
Atlanta, GA—Many patients with multiple myeloma succumb to infection before they have a chance to benefit from cancer therapy, according to a new study from Sweden.
More than 20% of patients died of infection within a year of myeloma diagnosis. Patients had heightened susceptibility to bacterial and viral pathogens, reported Cecilie Blimark, MD, a consultant hematologist at Sahlgrenska University Hospital, Gothenburg, Sweden, at the 2012 American Society of Hematology meeting.[ Read More ]
Boston, MA—Patients with prostate cancer reported significantly better sexual function for up to 2 years after radiation therapy when they took sildenafil (Viagra) on a daily basis during and after treatment, according to results of a placebo-controlled clinical trial.
Scores on the erectile function domain of the International Index of Erectile Function (IIEF) remained significantly better with sildenafil compared with placebo throughout the follow-up.[ Read More ]
Boston, MA—Patients with ALK-positive non–small-cell lung cancer (NSCLC) continued with crizotinib therapy more than twice as long when drug-resistant lesions were managed with local ablation, as shown by the results of a small clinical trial presented at the 2012 American Society for Radiation Oncology meeting.[ Read More ]
An 8-gene panel has demonstrated potential for identifying patients with estrogen receptor (ER)-positive and HER2-negative breast cancer at low risk for late metastasis. Patients classified as low risk by the EndoPredict panel had a significantly lower rate of distant metastasis after 5 and 10 years of follow-up compared with patients who did not meet the test’s criteria for low risk, according to Peter Dubsky, MD, of the Breast Health Center, Associate Professor of Surgery, Medical University of Vienna, Austria.
[ Read More ]
Low-dose intraoperative radiation therapy has proved comparable with whole-breast irradiation for preventing breast cancer recurrence, according to the preliminary results of the large randomized Targeted Intraoperative Radiotherapy (TARGIT-A) trial.
After a median follow-up of 29 months, the estimated 5-year absolute difference in relapses is 2.0% in favor of whole-breast irradiation. Although this numerically favors whole-breast irradiation, the difference is still within the 2.5% margin established for noninferiority.
[ Read More ]
Ten-year disease control in patients with nonmetastatic breast cancer did not differ significantly between patients treated with a reduced-dose hypofractionated radiation therapy compared with a standard protocol, according to a study presented at the meeting.
The 10-year locoregional recurrence rate was 4.3% in patients who received a 40-Gy radiation dose in 15 fractions and 5.5% in patients randomized to 50 Gy in 25 fractions.
[ Read More ]
San Francisco, CA—Patient survival after minimally invasive gastrectomy was identical with robotic-assisted and conventional laparoscopic surgery, according to data from a large patient series that was presented at the 2013 Gastrointestinal Cancers Symposium.
Both techniques led to 5-year 94% overall survival and 92% disease-free survival rates. Disease stage did not significantly alter survival results.
San Francisco, CA—Less proved to be the equivalent of more in a randomized comparison of empty versus chemotherapy-filled embolization beads for the treatment of patients with hepatocellular carcinoma (HCC), as shown in the results of a randomized study presented at the 2013 Gastrointestinal Cancers Symposium.[ Read More ]
Washington, DC—More than 50% of patients with difficult-to-treat chronic lymphocytic leukemia (CLL) had tumor shrinkage during 6 months of treatment with ibrutinib, results of a phase 2 clinical trial showed.[ Read More ]
Los Angeles, CA—Early palliative care proved to be cost-effective and cost-saving versus routine end-of-life care for patients with recurrent platinum-resistant ovarian cancer, according to a decision-model analysis.[ Read More ]
Los Angeles, CA—Neoadjuvant chemotherapy for older patients with ovarian cancer would save $19 million annually compared with primary debulking surgery, based on a new cost- model assessment.[ Read More ]
Washington, DC—A chemotherapy–immunotherapy combination has been shown to be extremely effective in a small clinical trial of previously untreated mantle-cell lymphoma, leading to objective responses in every patient, including complete responses in almost 90%, investigators reported at the 2013 American Association for Cancer Research annual meeting.[ Read More ]
Washington, DC—A positive fluorodeoxyglucose-positron emission tomography (FDG-PET) scan distinguished patients with high-risk stage I non–small-cell lung cancer (NSCLC) who may benefit from adjuvant chemotherapy, a retrospective review of a large database showed.
[ Read More ]
Los Angeles, CA—Most women with ovarian cancer receive substandard care that significantly reduces their survival odds, based on a new retrospective review of 13,000 patients that was presented at the 2013 Society of Gynecologic Oncology annual meeting.[ Read More ]
San Diego, CA—Prostate cancer screening with prostate-specific antigen (PSA) tests should focus on men aged 55 to 69 years, the group that is the most likely to benefit from screening, according to a new clinical guideline issued by the American Urological Association (AUA) at its 2013 annual meeting. This represents a significant shift from the previous position held by the AUA for strong support of PSA screening for men of all age-groups.[ Read More ]
Washington, DC—Black women had worse survival across all breast cancer subtypes, indicating that the survival disparity compared with white women cannot be blamed entirely on more frequent diagnosis of less treatable subtypes, based on data from a breast cancer survivor study.
Consistent with previous data, black women more often had difficult-to-treat triple-negative breast cancer and were less likely than white women to have the more treatable luminal A subtype. Mortality was twice as high in blacks as in whites, as documented in most studies.[ Read More ]
Washington, DC—Therapeutic development in head and neck cancer could eventually hone in on a handful of gene-expression patterns and signaling pathways that can identify a few discrete subtypes of the disease, data from The Cancer Genome Atlas suggest.
Sequencing of the entire tumor genome of 279 patients revealed 18 frequently mutated genes, of which expression patterns in squamous-cell carcinoma of the head and neck have simplified the search for new, more effective therapies.[ Read More ]
Washington, DC—Analysis of circulating DNA provides information about secondary mutations that cause drug resistance in patients with previously treated gastrointestinal stromal tumors (GISTs), reported George D. Demetri, MD, Director of the Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Boston, at the 2013 American Association for Cancer Research meeting.[ Read More ]
Children with acute lymphoblastic leukemia (ALL) had no drop-off in efficacy with an anthracycline-free regimen that also reduced the long-term risk of cardiotoxicity, reported Andre Baruchel, MD, PhD, Chief of Pediatric Hematology, Robert Debré University Hospital, Paris, France.
Induction therapy without daunorubicin (Cerubidine) led to a 5-year event-free survival (EFS) rate of almost 97%, slightly better than the rate observed in children who received conventional induction that included the anthracycline agent.[ Read More ]
A long-standing treatment standard for indolent non-Hodgkin lymphoma (NHL) has fallen victim to the chopping block, so to speak, at least in Germany.
The use of the cyclophosphamide (Cytoxan), doxorubicin (Adriamycin), vincristine (Oncovin), and prednisone (Deltasone; CHOP) regimen with or without rituximab (Rituxan; R-CHOP) has declined rapidly with the emergence of bendamustine (Treanda), which is used either alone or with rituximab.[ Read More ]
San Diego, CA—Getting technical information about companion diagnostic tests required to make formulary decisions about oncology drugs may not be easy, according to a small telephone survey conducted by Aashish Surti, PharmD candidate, and Iris Tam, PharmD, Director, Managed Care Medical Communications, Genentech. They reported their survey results in a poster presented at the 2013 Academy of Managed Care Pharmacy (AMCP) meeting.[ Read More ]
San Diego, CA—Evidence-based drug sequencing should form the basis of treatment for castration-resistant prostate cancer (CRPC), according to a new guideline from the American Urological Association (AUA) released at the 2013 AUA annual meeting.
Organized into strategies for 6 types of patients with CRPC (“index patients”), the guideline emphasizes therapies that have demonstrated efficacy in the specific index patient.[ Read More ]
An aromatase inhibitor has joined tamoxifen (Nolvadex) and the selective estrogen receptor (ER) modulator raloxifene hydrochloride (Evista) as chemoprevention for women who are at an increased risk for breast cancer, according to the recent update of the American Society of Clinical Oncology (ASCO) practice guideline (Visvanathan K, et al. J Clin Oncol. 2013;31:2942-2962).[ Read More ]
An evolving crisis in cancer care will reach a critical mass over the next 15 to 20 years without a transition to a more patient-centered, evidence-based delivery system, warn the authors of a report from the Institute of Medicine (IOM).[ Read More ]
San Diego, CA—Current economic trends mandate the development of innovative strategies to affect quality and efficiency in cancer care, applying the same rigor as used in clinical trials, according to Lee N. Newcomer, MD, MHA, Senior Vice President, UnitedHealthcare, who addressed cost issues and barriers in provider reimbursement at the 2013 ASCO Quality Care Symposium.[ Read More ]
San Diego, CA—The Patient-Reported Outcomes Measurement Information System (PROMIS) tool can inform clinical care delivery for patients with cancer, according to the initial results of a National Institutes of Health (NIH)-funded project.[ Read More ]
San Diego, CA—A new sense of urgency surrounds the need to improve quality measurement, even as major gaps persist in existing measures, said Jennifer L. Malin, MD, PhD, Medical Director, Oncology, WellPoint, at the 2013 ASCO Quality Care Symposium.[ Read More ]
San Diego, CA—Unnecessary treatment, imaging, and testing all came into focus in the American Society of Clinical Oncology (ASCO)’s 2013 choices for the Choosing Wisely campaign to eliminate the overuse and misuse of medical care resources.[ Read More ]
Atlanta, GA—Surgery and stereotactic body radiotherapy (SBRT) proved cost-effective strategies for stage I non–small-cell lung cancer (NSCLC) when applied to specific patient populations, according to a study reported at the 2013 American Society for Radiation Oncology meeting.
SBRT had the advantage for older patients with marginally operable disease, whereas lobectomy offered the most cost-effective option for patients with clearly operable disease.[ Read More ]
Atlanta, GA—The adoption of positron emission tomography (PET) imaging for the management of patients with non–small-cell lung cancer (NSCLC) has had a mixed impact on clinical and economic outcomes, according to findings from a large retrospective cohort study.[ Read More ]
Amsterdam, The Netherlands—Treatment with the oral angiogenesis inhibitor cediranib led to significant improvements in overall survival (OS) and progression-free survival (PFS) in patients with recurrent ovarian cancer, according to new data reported at the European Cancer Congress 2013.[ Read More ]
Amsterdam, The Netherlands—Expanded radiotherapy led to significantly better disease-free survival (DFS) and metastasis-free survival (MFS) rates in women with early breast cancer, according to the results of a large study reported at the European Cancer Congress 2013.[ Read More ]
Atlanta, GA—Patients with cancer treated with pelvic radiation did not have fewer bouts of diarrhea when treated prophylactically with the anti-inflammatory drug sulfasalazine (Azulfidine), a randomized trial showed. Patients receiving sulfasalazine had radiation-associated severe diarrhea almost 3 times as often as patients receiving placebo.[ Read More ]
San Antonio, TX—Breast cancer survivors obtained significant relief from aromatase inhibitor–associated joint pain with a prescribed exercise program, the results of a randomized clinical trial showed.
At the end of 1 year, the patients in the exercise group reported 20% to 30% less pain compared with a control group that was randomized to usual care. The benefits were consistent across subgroups, irrespective of age, disease stage, treatment regimen, or duration of aromatase inhibi-
San Antonio, TX—Patients with HER2-positive breast cancer harboring a PIK3CA mutation had a significantly lower likelihood of achieving a pathologic complete response (pCR) to neoadjuvant anti-HER2 therapy, the results of 2 large clinical trials presented at the 2013 San Antonio Breast Cancer Symposium (SABCS) showed.
Patients without the mutation had a pCR rate of 37% versus 17% for those with a mutation. The pCR rate for mutated tumors was 17% to 18%, whether patients received a single anti-HER2 agent or a combination.[ Read More ]
The quest for personalized medicine has come full circle with the US Food and Drug Administration (FDA)’s approval of the first high-throughput genomic sequencer, MiSeqDx, but challenges remain on several fronts before the technology’s full potential can be realized, according to the nation’s top health research administrator.[ Read More ]
San Diego, CA—The use of virtual patient vignettes to improve adherence to a breast cancer clinical pathway identified correctable variances from a breast cancer clinical pathway with the potential to reduce the cost of care by several million dollars, according to the results of a pilot study reported at the 2013 American Society of Clinical Oncology Quality Care Symposium. [ Read More ]
Scottsdale, AZ—Definitive chemoradiation with single-agent outpatient chemotherapy for head and neck cancer led to disease control and survival equivalent to that of inpatient multi-agent therapy, at an annualized savings of almost $650,000, according to results of a small randomized trial presented at the 2014 Multidisciplinary Head and Neck Cancer Symposium. [ Read More ]
Scottsdale, AZ—The addition of chemotherapy to irradiation proved superior to accelerated radiotherapy without systemic therapy in a randomized trial of patients with advanced head and neck cancer. [ Read More ]
San Francisco, CA—Men with castration-resistant prostate cancer (CRPC) had inferior time duration to prostate-specific antigen (PSA) progression and of progression-free survival (PFS) if they received the androgen receptor agonist enzalutamide (Xtandi) after the taxane docetaxel (Taxotere) rather than before, according to data from a retrospective study presented at the 2014 Genitourinary Cancers Symposium. [ Read More ]
The promise of big data–driven personalized healthcare mandates reform of the oncology reimbursement system, suggested Jeffery C. Ward, MD, Medical Oncologist, Swedish Cancer Institute, Edmonds, WA, in a recent commentary. [ Read More ]
San Francisco, CA—Magnetic resonance imaging (MRI)-guided brachytherapy led to significantly less urinary dysfunction in men being treated for localized prostate cancer compared with ultrasound-guided techniques, according to a long-term prospective cohort study reported at the 2014 Genitourinary Cancers Symposium. [ Read More ]
San Diego, CA—Palbociclib, an inhibitor of cyclin-dependent kinase (CDK) 4/6, demonstrated “striking” activity when combined with conventional hormone therapy for patients with metastatic breast cancer, according to the results of an open-label phase 2 trial presented at the 2014 American Association for Cancer Research annual meeting. [ Read More ]
San Diego, CA—Almost 50% of patients with metastatic renal-cell carcinoma (mRCC) had objective responses to third-line treatment with the angiogenesis inhibitor pazopanib, according to the results of a small clinical trial reported at the 2014 American Association for Cancer Research annual meeting. [ Read More ]
San Diego, CA—A multitargeted kinase inhibitor met criteria for a phase 3 clinical trial in breast cancer after statistical modeling of clinical data showed a high probability of success versus standard therapy for patients with HER2-positive/hormone receptor (HR)-negative (HER2+/HR–) disease. [ Read More ]
Tampa, FL—Prophylactic salpingo- oophorectomy did not eliminate the risk for a rare but aggressive form of uterine cancer in women with BRCA1 mutations, according to a study reported at the 2014 Society of Gynecologic Oncology meeting. [ Read More ]
Tampa, FL—Women with gynecologic cancers had significantly better survival when treated at high-volume centers, according to a review of 863,000 cases reported at the 2014 Society of Gynecologic Oncology meeting. [ Read More ]
Tampa, FL—The poly (ADP-ribose) polymerase (PARP) inhibitor veliparib demonstrated activity in relapsed and/or refractory BRCA-mutated ovarian cancer, according to the results of a phase 2 clinical trial reported at the 2014 Society of Gynecologic Oncology meeting. [ Read More ]
San Diego, CA—Tobacco researchers and regulators lauded progress in tobacco control, but they emphasized that the health burden of tobacco use continues, reflecting the expanding list of diseases caused or exacerbated by tobacco. [ Read More ]
The high cost of cancer care follows patients well into survivorship, as annual medical costs and losses in productivity exceed those of people without cancer by 50% to 100%, a study for the Centers for Disease Control and Prevention (CDC) showed [ Read More ]
Madrid, Spain—The positive results from 2 studies raised speculation about a possible resurrection of the breast cancer indication for bevacizumab, as reported at the 2014 European Society for Medical Oncology Congress. [ Read More ]
Madrid, Spain—Continuing an EGFR inhibitor after acquired resistance does not slow the progression of advanced non–small-cell lung cancer (NSCLC) in patients receiving chemotherapy, according to a report presented at the 2014 European Society for Medical Oncology (ESMO) Congress. However, extending anti-EGFR therapy with erlotinib beyond disease progression may be beneficial, according to a second report presented at the meeting. [ Read More ]
San Francisco, CA—Preoperative breast magnetic resonance imaging (MRI) failed to influence clinical management in any subgroup of 257 patients with breast cancer, according to the results of a retrospective review that led one cancer center to discontinue the practice. [ Read More ]
San Francisco, CA—Patients with breast cancer who attended survivorship clinics demonstrated improved compliance with follow-up visits, increased use of supportive services, and felt their concerns were better addressed, according to the results of a cancer center’s patient survey reported by Leah L. Dietrich, MD, an oncologist at Gundersen Health System, La Crosse, WI, at the 2014 Breast Cancer Symposium. [ Read More ]
San Antonio, TX—Adding an erythropoiesis-stimulating agent (ESA) to best supportive care failed to demonstrate noninferiority for progression-free survival (PFS) compared with best supportive care alone in patients with metastatic breast cancer, in a clinical trial known as EPO-ANE-3010 that was requested by the FDA. [ Read More ]
Chicago, IL—Poly (ADP-ribose) polymerase (PARP) inhibitor maintenance therapy with olaparib (Lynparza) for relapsed, platinum-sensitive ovarian cancer would meet conventional standards of cost-effectiveness only if the drug price decreased by ?66%, according to a modeling study. [ Read More ]
Comprehensive Cancer Center Designation Trumps High Volume as Predictor for Outcomes in Ovarian Cancer
Chicago, IL—The National Cancer Institute (NCI) designation of a comprehensive cancer center trumps high case volume as a predictor of outcomes in ovarian cancer, according to a single-region analysis. [ Read More ]
All patients with smoldering or asymptomatic multiple myeloma should undergo whole-body magnetic resonance imaging (MRI), or pelvic and spinal MRI if whole body is unavailable, according to recommendations from the International Myeloma Working Group (IMWG). The presence of >1 focal lesions >5 mm should be considered diagnostic for symptomatic myeloma requiring therapy. [ Read More ]
A revised survivorship care plan template addresses obstacles that have limited the use of survivorship plans in clinical practice, suggested an American Society of Clinical Oncology (ASCO) expert panel headed by Deborah K. Mayer, PhD, MSN, RN, Professor of Nursing and Director of Survivorship Care, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill. [ Read More ]
The use of therapy with chimeric antigen receptor (CAR)-modified T-cells consistently demonstrated activity in advanced hematologic malignancies, including different types of lymphoma, in multiple trials reported at ASH 2015. [ Read More ]
Patients with previously treated metastatic urothelial cancer had response rates that exceeded historical standards when treated with an investigational immunotherapeutic agent, updated results of a large phase 2 clinical trial showed. Treatment with the PD-1 ligand 1 (PD-L1) inhibitor atezolizumab led to an overall response rate of 15% in 311 patients, including a 26% rate among patients who had the highest levels of PD-L1 expression. Historical data have demonstrated response rates of about 10% for second-line therapy and beyond. [ Read More ]
A panel of 4 blood-derived biomarkers showed promise as an aid to early detection of colorectal cancer (CRC). The panel yielded a negative predictive value exceeding 90% for CRC, the combination of CRC and high-risk adenomas, and colorectal plus other cancers. The biomarker assay demonstrated fair to good performance characteristics, associated with the receiver operating characteristic (ROC) curve ranging between 0.70 and 0.80. [ Read More ]
Increased levels of physical activity after a diagnosis of prostate cancer are associated with significantly better survival, according to the results of a new, large prospective cohort study (Friedenreich CM, et al. Eur Urol. 2016 Jan 7. Epub ahead of print). [ Read More ]
Immune checkpoint inhibitors demonstrated varying degrees of activity in advanced gastric and esophageal cancers, according to preliminary clinical studies reported at the 2016 Gastrointestinal Cancers Symposium. The objective response rates ranged from 9% to 30% with 3 different PD-1 or [ Read More ]
The advantages of treatment at a high-volume center extended to adjuvant therapy in patients with resected pancreatic cancer, according to a study reported by Margaret T. Mandelson, PhD, MPH, Floyd and Dolores Jones Cancer Institute, Virginia Mason Medical Center, Seattle, [ Read More ]
The first-in-class cancer stem-cell inhibitor BBI608 demonstrated activity in advanced pancreatic cancer and colorectal cancer (CRC), according to results of 2 small studies reported at the 2016 Gastrointestinal Cancers Symposium. Approximately 50% of 31 patients with heavily pretreated pancreatic cancer [ Read More ]
All women with ovarian cancer should be offered genetic testing regardless of tumor histology, said Barbara S. Norquist, MD, gynecologic oncologist, University of Washington, Seattle, at the 2016 Society of Gynecologic Oncology meeting. She presented the results of a retrospective, tissue-based analysis of a randomized clinical trial. [ Read More ]
Women with clinicopathologic high-risk breast cancer had nearly a 50% reduction in prescription chemotherapy, with no increased risk for metastatic recurrence when a cancer gene-based assay was used to guide treatment decision-making, according to new data presented at the 2016 American Association for Cancer Research meeting. [ Read More ]
An ongoing clinical trial of a novel strategy to evaluate new chemotherapy regimens for patients with early-stage breast cancer has identified another neoadjuvant combination therapy worthy of a phase 3 clinical trial involving patients with HER2-positive breast cancer. [ Read More ]
More than 50% of women with early-stage endometrial cancer had open surgery, in contradiction to recommendations in clinical guidelines, according to a study reported at the 2016 Society of Gynecologic Oncology (SGO) annual meeting. [ Read More ]
The use of liposomal bupivacaine during major surgery for gynecologic malignancies achieved similar pain control with significantly less use of opioids and patient-controlled analgesia (PCA) as conventional bupivacaine. [ Read More ]
High-risk patients with metastatic renal-cell carcinoma (RCC) and venous tumor thrombus derived no benefit from cytoreductive nephrectomy and should be evaluated for clinical trials of systemic therapy, suggested a retrospective multicenter review. [ Read More ]
The multitargeted RAF inhibitor BGB-283 demonstrated activity in several types of advanced solid tumors associated with different mutations in the RAF family of genes, results of a preliminary clinical trial showed. [ Read More ]
The multitarget stool DNA test, a noninvasive screening tool for colorectal cancer (CRC), demonstrated potential for identifying cancer and advanced adenomas in community-based individuals who had previously not followed national screening recommendations, reported Mark Prince, MD, MBA, Director of Gastroenterology, USMD Health System, Arlington, TX, at the 2016 American Association for Cancer Research annual meeting. [ Read More ]
Every patient with cancer and cancer survivors should undergo screening for pain at each follow-up visit, and clinicians should individualize the recommendations for intervention as indicated by each patient’s self-reported pain, according to the first-ever clinical guidelines for managing pain in cancer survivors recently published by a panel of experts convened by the American Society of Clinical Oncology (ASCO). [ Read More ]
The incidence of metastatic prostate cancer increased by >70% from 2004 to 2013, including >90% in the age-group most likely to benefit from definitive treatment, according to a new analysis of a national database (Weiner AB, et al. Prostate Cancer Prostatic Dis. 2016 Jul 19. Epub ahead of print). [ Read More ]
Patient-reported outcomes had significant associations with survival in metastatic castration-resistant prostate cancer (mCRPC), suggesting potential implications for clinical management, reported Tomasz M. Beer, MD, Oregon Health & Science University, Knight Cancer Institute, Portland, and colleagues, at the 2016 International Society for Pharmacoeconomics and Outcomes Research annual meeting. [ Read More ]
Pancreatic cancer is the third leading cause of cancer-related death in the United States. Nearly half of patients with locoregional pancreatic cancer do not undergo potentially curative surgery, primarily because of nonclinical factors, according to the results of an analysis of data from the National Cancer Institute database by Amy T. Cunningham, MPH, a doctoral candidate at Thomas Jefferson University in Philadelphia, and colleagues. [ Read More ]
The number of cancers linked by scientific evidence to obesity has increased to 13, according to a recent special report by the International Association for Research on Cancer (IARC) Handbook Working Group (Lauby-Secretan B, et al. N Engl J Med. [ Read More ]
A novel 37-gene assay showed potential for classifying prostate cancer into 3 subtypes based on aggressiveness and likely response to therapy, reported Michael R. Freeman, PhD, Director, Division of Cancer Biology and Therapeutics Research, Cedars-Sinai Medical Center, Los Angeles, CA, and [ Read More ]
Washington, DC—Value assessments for the management of patients with metastatic colorectal cancer (mCRC) focus more on cost-effectiveness and less on the line of therapy, according to a study presented by Ed Wang, PharmD, Deputy Director, Health Economics and Outcomes Research, [ Read More ]
Nearly 20% of community-dwelling cancer survivors with depression received no treatment for their depression, according to an analysis of nationally representative data. Among patients whose records included International Classification of Diseases, Ninth Edition, Clinical Modification (ICD-9-CM) codes associated with depression, [ Read More ]
Recent advances in the management of thyroid cancer have evolved directly from improved knowledge of the underlying genetics and molecular biology, an understanding that will continue to improve in the future, according to a recent review. Recognition that thyroid cancer [ Read More ]
Washington, DC—The use of gene panels to guide decision-making in patients with metastatic colorectal cancer (mCRC) has no clear association with patient characteristics, according to the results of a preliminary single-center study presented at a poster session at the 2016 [ Read More ]
Copenhagen, Denmark—Two more PD-1 targeted drugs staked a claim to a role in treating advanced urothelial cancer, according to data from 2 studies that were reported at the 2016 European Society for Medical Oncology Congress. [ Read More ]
Copenhagen, Denmark—Adjuvant immunotherapy with ipilimumab (Yervoy) led to significant improvement in long-term overall survival (OS) among patients with high-risk melanoma, according to results from a 5.3-year follow-up in a randomized clinical trial reported at the 2016 European Society for Medical Oncology Congress and published simultaneously online. [ Read More ]
Copenhagen, Denmark—A novel approach to targeting the estrogen receptor (ER) led to improved progression-free survival (PFS) in postmenopausal women with advanced, hormone receptor (HR)-positive breast cancer, according to data from the FALCON clinical trial that were reported at the 2016 European Society for Medical Oncology Congress. [ Read More ]
Angiogenesis Inhibitor Has Modest Effect on Progression-Free Survival in Metastatic Colorectal Cancer
Copenhagen, Denmark—Patients with previously treated metastatic colorectal cancer (mCRC) had a small but significant improvement in progression-free survival (PFS) but no overall survival (OS) benefit after receiving the multikinase inhibitor nintedanib (Ofev), according to results from the LUME-Colon 1 clinical trial reported by principal investigator Eric Van Cutsem, MD, Clinical Digestive Oncology, University Hospitals Leuven, Belgium, at the 2016 European Society for Medical Oncology Congress. [ Read More ]
Ceritinib, a Newer ALK Inhibitor, Improves Progression-Free Survival After Crizotinib Failure in NSCLC
Copenhagen, Denmark—Patients with heavily pretreated ALK mutation and non–small-cell lung cancer (NSCLC) had significant improvement in progression-free survival (PFS) after receiving the next-generation ALK inhibitor ceritinib, according to results from the ASCEND-5 study reported at the 2016 European Society for Medical Oncology Congress by Giorgio Scagliotti, MD, Professor of Respiratory Medicine, University of Torino, Italy. [ Read More ]
Copenhagen, Denmark—Immunotherapy competition in non–small-cell lung cancer (NSCLC) continued to heat up as atezolizumab (Tecentriq) improved overall survival (OS) versus docetaxel, according to results from the randomized, phase 3 OAK clinical trial reported at the 2016 European Society for Medical Oncology Congress by Fabrice Barlesi, MD, Professor of Medicine, Aix-Marseille University, France. [ Read More ]